Effects of intrinsic and extrinsic factors were evaluated using a stepwise covariate modeling procedure in combination with the full covariate approach, and defined no-effect boundaries for exposure were based on the difference in exposure between 70 and 100 mg of roxadustat (i.e., - 30%, + 43%).
Non-linear mixed-effects models implemented in NONMEM software were fitted to 8209 pharmacokinetic samples from 2855 DD and NDD subjects enrolled in four phase III studies with roxadustat dose concentrations of 20-400 mg as orally administered tablets.
A population pharmacokinetic analysis was undertaken to evaluate the effect of intrinsic and extrinsic factors on roxadustat pharmacokinetics. This agent (roxadustat) is in clinical development for the treatment of anemia in patients with non-dialysis-dependent (NDD) and dialysis-dependent (DD) chronic kidney disease. Download Analysis of Chronic Diseases Progression Using Stochastic Modeling Books nowAvailable in PDF, EPUB, Mobi Format. Roxadustat is a novel, small-molecule, first-in-class therapeutic that stimulates erythropoiesis by inhibiting hypoxia-inducible factor prolyl hydroxylase enzymes. In children, AR is currently one of the most common chronic disorders and therefore anti-allergic drugs, particularly the antihistamines and intranasal steroids. Synopsis : Analysis of Chronic Diseases Progression Using Stochastic Modeling written by Iman Mohammed Attia Abd-Elkhalik, published by Iman Mohammed Attia Abd-Elkhalik which was released on 30 September 2021.